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M9650035.TXT
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1996-03-09
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Document 0035
DOCN M9650035
TI Concurrent thrombotic thrombocytopenic purpura and immune
thrombocytopenic purpura in an HIV-positive patient: case report and
review of the literature.
DT 9605
AU Yospur LS; Sun NC; Figueroa P; Niihara Y; Department of Pathology,
Harbor-UCLA Medical Center, Torrance; 90509, USA.
SO Am J Hematol. 1996 Jan;51(1):73-8. Unique Identifier : AIDSLINE
MED/96159001
AB Immune thrombocytopenic purpura (ITP) and thrombotic thrombocytopenic
purpura (TTP) have each been associated with HIV infection. Sequential
occurrence of these two diseases with a disease-free interval has been
occasionally reported in the literature, whereas simultaneous
manifestations of these two diseases have not been described. Here, we
report an AIDS patient who was initially diagnosed as having TTP and
showed an apparent partial response to plasmapheresis but was found to
have a clinical course similar to ITP. Although precise mechanisms for
the development of TTP and ITP in these patients are unclear, we offer
several hypotheses. It is important to recognize that these two
processes may be seen concurrently.
DE Acquired Immunodeficiency Syndrome/*COMPLICATIONS/IMMUNOLOGY Adult
Antibiotics, Combined/THERAPEUTIC USE Antiviral Agents/THERAPEUTIC USE
Autoimmune Diseases/*COMPLICATIONS/IMMUNOLOGY/THERAPY AIDS-Related
Opportunistic Infections/COMPLICATIONS Case Report Combined Modality
Therapy Erythrocyte Transfusion Fatal Outcome Female Human
Immunosuppressive Agents/THERAPEUTIC USE Plasma Plasmapheresis
Pneumonia, Pneumocystis carinii/COMPLICATIONS Purpura,
Thrombocytopenic, Idiopathic/*COMPLICATIONS/IMMUNOLOGY/ THERAPY
Purpura, Thrombotic Thrombocytopenic/*COMPLICATIONS/IMMUNOLOGY/
PHYSIOPATHOLOGY/THERAPY Sarcoma, Kaposi's/COMPLICATIONS JOURNAL
ARTICLE REVIEW REVIEW OF REPORTED CASES
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).